´¯`•. May 02, 2017

the Vaccinated vs. the Unvaccinated

First vaccinated vs unvaccinated study ever done finally published online.   Peer reviewed and published in the Journal of Translational Science.  You can read the entire study at the following link, but I’m posting just the conclusions.


Following a recommendation of the Institute of Medicine [19] for studies comparing the health outcomes of vaccinated and unvaccinated children, this study focused on homeschool children ages 6 to 12 years based on mothers’ anonymous reports of pregnancy-related conditions, birth histories, physician-diagnosed illnesses, medications and healthcare use. Respondents were mostly white, married, and college-educated, upper income women who had been contacted and invited to participate in the study by the leaders of their homeschool organizations. Data from the survey were also used to determine whether vaccination was associated specifically with NDDs, a derived diagnostic category combining children with the diagnoses of learning disability, ASD and/or ADHD.

With regard to acute and chronic conditions, vaccinated children were significantly less likely than the unvaccinated to have had chickenpox and pertussis but, contrary to expectation, were significantly more likely to have been diagnosed with otitis media, pneumonia, allergic rhinitis, eczema, and NDD. The vaccinated were also more likely to have used antibiotics, allergy and fever medications; to have been fitted with ventilation ear tubes; visited a doctor for a health issue in the previous year, and been hospitalized. The reason for hospitalization and the age of the child at the time were not determined, but the latter finding appears consistent with a study of 38,801 reports to the VAERS of infants who were hospitalized or had died after receiving vaccinations. The study reported a linear relationship between the number of vaccine doses administered at one time and the rate of hospitalization and death; moreover, the younger the infant at the time of vaccination, the higher was the rate of hospitalization and death [55]. The hospitalization rate increased from 11% for 2 vaccine doses to 23.5% for 8 doses (r2 = 0.91), while the case fatality rate increased significantly from 3.6% for those receiving from 1-4 doses to 5.4 % for those receiving from 5-8 doses.

In support of the possibility that the number of vaccinations received could be implicated in risks of associated chronic illness, a comparison of unvaccinated, partially and fully vaccinated children in the present study showed that the partially vaccinated had increased but intermediate odds of chronic disease, between those of unvaccinated and fully vaccinated children, specifically for allergic rhinitis, ADHD, eczema, a learning disability, and NDD as a whole.

The national rates of ADHD and LD are comparable to those of the study. The U.S. rate of ADHD for ages 4-17 (twice the age range of children than the present study), is 11% [31]. The study rate of ADHD for ages 6 to 12 is 3.3%, and 4.7% when only vaccinated children are included. The national LD rate is 5% [32], and the study data show a rate of LD of 3.9% for all groups, and 5.6% when only vaccinated children are included. However, the ASD prevalence of 2.24% from a CDC parent survey is lower than the study rate of 3.3%. Vaccinated males were significantly more likely than vaccinated females to have been diagnosed with allergic rhinitis, and NDD. The percentage of vaccinated males with an NDD in this study (14.4%) is consistent with national findings based on parental responses to survey questions, indicating that 15% of U.S. children ages 3 to 17 years in the years 2006-2008 had an NDD [28]. Boys are also more likely than girls to be diagnosed with an NDD, and ASD in particular [29].

…The second aim of the paper focused on a specific health outcome and sought to determine whether vaccination remained associated with neurodevelopmental disorders (NDD) after controlling for other measured factors. After adjustment, the factors that remained significantly associated with NDD were vaccination, nonwhite race, male gender, and preterm birth. The apparently strong association between both vaccination and preterm birth and NDD suggested the possibility of an interaction between these factors. This was shown in a final adjusted model with interaction (controlling for the interaction of preterm birth with vaccination). In this model, vaccination, nonwhite race and male gender remained associated with NDD, whereas preterm birth itself was no longer associated with NDD. However, preterm birth combined with vaccination was associated with a 6.6-fold increased odds of NDD.

In summary, vaccination, nonwhite race, and male gender were significantly associated with NDD after controlling for other factors. Preterm birth, although significantly associated with NDD in unadjusted and adjusted analyses, was no longer associated with NDD in the final model with interaction. However, preterm birth and vaccination combined was strongly associated with NDD in the final adjusted model with interaction, more than doubling the odds of NDD compared to vaccination alone. Preterm birth has long been known as a major factor for NDD [68,69], but since preterm infants are routinely vaccinated, the separate effects of preterm birth and vaccination have not been examined. The present study suggests that vaccination could be a contributing factor in the pathogenesis of NDD but also that preterm birth by itself may have a lesser or much reduced role in NDD (defined here as ASD, ADHD and/or a learning disability) than currently believed. The findings also suggest that vaccination coupled with preterm birth could increase the odds of NDD beyond that of vaccination alone.

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